How aging affects muscle regeneration and exercise response
Official title: PHD2 mediated loss of hypoxia signaling limits skeletal muscle regeneration and exercise response in aging
Funded at Brigham and Women's Hospital · NIH-11077326 · Data updated 2026-11-12
This study is looking at how aging affects muscle recovery and exercise ability by focusing on a specific enzyme that increases as we get older, and it aims to find new ways to help older adults keep their muscles strong and healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $384,166 |
| NIH project number | 5R01AG078307-03 |
| Project ID | NIH-11077326 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing muscle loss or decreased exercise capacity.
✕Less likely to help
Patients who are not elderly or do not have issues related to muscle regeneration or exercise adaptation may not benefit from this research.
What this research studies
This research investigates how the loss of hypoxia signaling in skeletal muscle due to aging impacts muscle regeneration and the ability to adapt to aerobic exercise. Using mouse models, the study focuses on the role of the enzyme PHD2, which increases with age and disrupts important signaling pathways necessary for muscle health. By understanding these mechanisms, the research aims to develop new treatment strategies to maintain muscle mass and function in older adults.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that help preserve muscle mass and improve exercise capacity in the elderly.
How similar studies have gone: Other research has shown promising results in understanding muscle regeneration and signaling pathways in aging, indicating that this approach has potential for success.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Sinha, Indranil — Brigham and Women's Hospital
- Study coordinator: Sinha, Indranil
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.