How aging affects muscle metabolism in a 3D muscle tissue model
Official title: Metabolic response to contraction in a 3D engineered muscle tissue model of aging
Funded at University of Washington · NIH-10948409 · Data updated 2026-11-12
This study looks at how getting older affects how our muscles work when we exercise, using a special model to mimic muscle contractions, and it aims to help us understand how to keep our muscles healthy as we age.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $485,375 |
| NIH project number | 1R21AG088504-01 |
| Project ID | NIH-10948409 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing muscle weakness or frailty.
✕Less likely to help
Patients who are younger and do not have any muscle-related issues may not benefit from this research.
What this research studies
This research investigates how aging impacts the metabolic response of muscle tissue during contraction using a three-dimensional engineered muscle model. By simulating different types of muscle contractions, the study aims to understand the changes in mitochondrial function and fatty acid oxidation in aged muscle compared to younger muscle. The research employs advanced techniques to analyze how exercise influences muscle metabolism and may lead to insights on preventing age-related muscle decline.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving muscle health and function in older adults.
How similar studies have gone: Previous research has shown promising results in understanding muscle metabolism through similar experimental approaches, indicating potential for success in this study.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Campbell, Matthew D — University of Washington
- Study coordinator: Campbell, Matthew D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.