How aging affects liver cancer using mouse models
Core B: Mouse Models of Aging and Cancer
['FUNDING_P01'] · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · NIH-11160729
Researchers are using mouse models to learn how aging in the liver contributes to liver cancer so future prevention or treatments might help people at risk.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11160729 on ClinicalTrials.gov |
What this research studies
This core provides and maintains mouse models to study how age-related changes in the liver promote cancer. It performs animal procedures such as injections, viral or DNA delivery, modified diets, and cell transplantation, and monitors tumors with imaging and regular health checks. Tissues are collected, banked, and examined by histopathology and molecular analyses, and data are stored in searchable colony and tissue databases. The core also offers training and protocol support for project teams who work on liver aging and cancer.
Who could benefit from this research
Good fit: People with liver cancer, those at high risk because of age or chronic liver disease, or individuals willing to donate tissue or participate in future clinical studies would be the most relevant candidates for follow-up research.
Not a fit: People without liver disease or those seeking immediate clinical treatment are unlikely to receive direct benefit from this preclinical mouse-model work.
Why it matters
Potential benefit: If successful, this work could reveal aging-related changes that lead to new ways to prevent, detect, or treat liver cancer in older adults.
How similar studies have performed: Mouse-model studies have previously identified aging-related pathways linked to cancer, but translating those findings into human treatments remains an ongoing challenge.
Where this research is happening
LA JOLLA, UNITED STATES
- SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SACCO, ALESSANDRA — SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- Study coordinator: SACCO, ALESSANDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers