How aging affects kidney cell health and function
Autocrine and paracrine podocyte signals decrease glomerular function/health in aged kidneys
This study is looking at how aging affects important kidney cells called podocytes and how changes in these cells might lead to kidney problems in older adults, with the hope of finding new ways to keep kidneys healthy as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10892169 on NIH RePORTER |
What this research studies
This research investigates the role of aging in kidney health, specifically focusing on podocytes, which are crucial cells in the kidney. It aims to understand how these cells change with age and how their interactions with neighboring cells contribute to kidney disease in elderly patients. By analyzing kidney cells from both young and aged mice, the researchers are looking to identify inflammatory signals that may lead to reduced kidney function. The findings could help develop new strategies to improve kidney health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals experiencing kidney health issues or those at risk of developing kidney disease.
Not a fit: Patients who are not elderly or do not have kidney-related health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance kidney function and health in elderly patients.
How similar studies have performed: Other research has shown promising results in understanding the role of cellular aging in kidney disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Shankland, Stuart James — University of Washington
- Study coordinator: Shankland, Stuart James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.