How aging affects inflammation in brain cells and its genetic regulation
Age-dependent activation of microglia inflammatory state and its epigenetic modulation
This study is looking at how getting older affects the brain's immune cells and how our genes might play a role in this process, which could help us understand more about conditions like Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10875735 on NIH RePORTER |
What this research studies
This research investigates how aging influences the inflammatory state of microglia, the brain's immune cells, and how this process is regulated by genetic factors. By studying mice, the researchers aim to understand how previous exposure to inflammation can lead to heightened inflammatory responses in aging microglia. The study will involve inducing temporary inflammation in mice and analyzing the resulting changes in gene expression at various ages. This approach may help uncover the underlying mechanisms that contribute to neurodegenerative diseases like Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who may be at risk for Alzheimer's disease or other neurodegenerative conditions.
Not a fit: Patients who are not experiencing age-related cognitive decline or do not have a history of inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting inflammation in the brain.
How similar studies have performed: Other research has shown promising results in understanding the role of inflammation in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Schaefer, Anne — Icahn School of Medicine at Mount Sinai
- Study coordinator: Schaefer, Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.