How aging affects inflammation and fat accumulation in bones
Immunometabolic regulation of bone inflammaging
This study is looking at how getting older, inflammation, and fat in our bones are connected, and it wants to find out if changing how our nervous system works can help prevent bone loss and inflammation as we age, especially for older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11076294 on NIH RePORTER |
What this research studies
This research investigates the relationship between aging, inflammation, and fat accumulation in bones, which can lead to conditions like osteoporosis. It explores how the sympathetic nervous system influences these processes by regulating the release of certain chemicals that affect fat metabolism. The study aims to understand whether targeting these mechanisms can prevent bone loss and inflammation associated with aging. By examining both human and mouse models, the research seeks to uncover potential therapeutic strategies for improving bone health in the elderly.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing bone loss or related conditions such as osteoporosis.
Not a fit: Patients who are younger and do not have issues related to bone health or inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent bone loss and improve overall bone health in older adults.
How similar studies have performed: Other research has shown promising results in understanding the role of inflammation and fat metabolism in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Dixit, Vishwa Deep — Yale University
- Study coordinator: Dixit, Vishwa Deep
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.