How aging affects immune cells and bone health
Role of Macrophage in Osteoimmunology with Aging
This study is looking at how certain immune cells affect bone health as we get older, especially in helping to understand osteoporosis, and it aims to find new ways to keep bones strong in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11023064 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells, known as T helper cells and macrophages, in the regulation of bone health as people age. It focuses on understanding how these cells interact with bone cells to disrupt bone homeostasis, leading to conditions like age-related osteoporosis. The study aims to identify mechanisms by which certain proteins influence bone formation and degradation, particularly in older adults. By exploring these interactions, the research seeks to uncover potential therapeutic targets for improving bone health in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing bone loss or osteoporosis, particularly those with autoimmune conditions.
Not a fit: Patients who are younger and do not have osteoporosis or autoimmune disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse bone loss in older adults.
How similar studies have performed: Other research has shown promising results in understanding immune cell interactions with bone health, suggesting that this approach could lead to significant advancements.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Yao, Zhenqiang — University of Rochester
- Study coordinator: Yao, Zhenqiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.