How aging affects immune cell function and inflammation
Mitochondrial determinants of monocyte dysfunction in aging
['FUNDING_R15'] · UNIVERSITY OF MEMPHIS · NIH-10514864
This study is looking at how getting older affects certain immune cells called monocytes, which play a key role in managing inflammation, and it aims to find a way to improve their function through a new method that involves using healthy cell parts, so we can better understand and potentially help with age-related immune issues.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MEMPHIS (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10514864 on ClinicalTrials.gov |
What this research studies
This research investigates how aging impacts the function of monocytes, which are important immune cells that help regulate inflammation. The study aims to understand the metabolic changes in these cells due to aging and how these changes contribute to immune dysfunction and chronic inflammation. Researchers will explore a novel approach to restore the metabolic function of aged monocytes through mitochondrial transplantation, using both human and mouse models to validate their findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing immune dysfunction or chronic inflammatory conditions.
Not a fit: Patients who are younger or do not have any immune dysfunction or chronic inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve immune function and reduce inflammation in older adults.
How similar studies have performed: While the specific approach of mitochondrial transplantation in this context is novel, previous research has shown promising results in understanding the link between metabolism and immune function in aging.
Where this research is happening
MEMPHIS, UNITED STATES
- UNIVERSITY OF MEMPHIS — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PENCE, BRANDT D. — UNIVERSITY OF MEMPHIS
- Study coordinator: PENCE, BRANDT D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Disease, acute disease/disorder, acute disorder