How aging affects energy use and fatigue in older adults with HIV
Official title: Mitochondrial energetics, exercise intolerance and fatigability in older people with HIV
Funded at Johns Hopkins University · NIH-10623185 · Data updated 2026-11-12
This study looks at how getting older affects energy use and exercise ability in older adults with HIV, aiming to understand how muscle function and other factors like inflammation might be linked to tiredness and weakness, all to help improve their quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | June 15, 2019 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $587,747 |
| NIH project number | 5R01AG063661-05 |
| Project ID | NIH-10623185 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 50 and above who are living with HIV and experiencing fatigue or exercise intolerance.
✕Less likely to help
Patients who are younger than 50 or do not have HIV may not benefit from this research.
What this research studies
This research investigates how aging impacts energy metabolism and exercise tolerance in older adults living with HIV. It focuses on understanding the role of mitochondrial function in muscle energy use and how this relates to fatigue and frailty. Using advanced imaging techniques, the study aims to identify the underlying mechanisms that contribute to decreased physical performance in this population. By examining factors like inflammation and lipid accumulation in muscle tissue, the research seeks to provide insights into improving quality of life for older individuals with HIV.
Why it matters
Potential benefit: If successful, this research could lead to targeted interventions that enhance physical function and quality of life for older adults living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial function in other populations, suggesting potential for success in this area as well.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Weiss, Robert G — Johns Hopkins University
- Study coordinator: Weiss, Robert G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.