How aging affects energy metabolism in bone cells
Osteocyte energy metabolism in aging
This study looks at how aging affects bone cells called osteocytes and their energy use, with the goal of finding ways to help improve bone health in older adults, especially when it comes to how these cells react to physical activity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10873919 on NIH RePORTER |
What this research studies
This research investigates the impact of aging on osteocytes, the primary cells in bone, and how their energy metabolism changes over time. It aims to understand the mechanisms that lead to impaired bone health in older adults, particularly focusing on how these cells respond to mechanical loading. By studying the regulation of energy metabolism in osteocytes, the research seeks to identify potential therapeutic targets to improve bone health in the elderly. The approach includes both in vitro and in vivo experiments to assess the effects of mechanical strain on energy metabolism.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related bone loss or those at risk of osteoporosis.
Not a fit: Patients who are younger and do not have any bone health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance bone health and reduce the risk of fractures in older adults.
How similar studies have performed: Previous research has shown promising results in understanding energy metabolism in aging, suggesting that this approach may yield valuable insights.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Kitase, Yukiko — Indiana University Indianapolis
- Study coordinator: Kitase, Yukiko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.