How aging affects different types of bone in older adults
Different consequences of cellular aging in cortical versus cancellous bone- Resubmission
This study looks at how getting older affects different types of bones and how changes in our bones can lead to fractures, using aged mice to find out more about these changes, with the hope of discovering new ways to keep bones healthy as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project ID | NIH-11005385 on NIH RePORTER |
What this research studies
This research investigates the effects of aging on two types of bone: cortical and cancellous. It examines how cellular changes in the skeleton of older adults lead to different patterns of bone loss, which can contribute to fractures. By studying aged mice, the research aims to uncover the molecular mechanisms behind these changes, focusing on cellular senescence and DNA damage. The findings could help identify new treatments to improve bone health in older individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing age-related bone health issues.
Not a fit: Patients under the age of 65 or those without age-related bone health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance bone health and reduce fracture risk in older adults.
How similar studies have performed: Previous research has shown promising results in understanding cellular aging and its impact on bone health, suggesting that this approach could yield valuable insights.
Where this research is happening
Little Rock, United States
- Univ of Arkansas for Med Scis — Little Rock, United States (Active)
Researchers
- Principal investigator: Almeida, Maria Jose — Univ of Arkansas for Med Scis
- Study coordinator: Almeida, Maria Jose
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.