How aging affects communication between the kidneys, adrenal glands, and heart
Official title: Age remodels kidney-adrenal-heart interorgan communication
Funded at Brown University · NIH-11083045 · Data updated 2026-11-12
This study is looking at how getting older affects the way our kidneys, adrenal glands, and heart work together, which can cause health issues, and it’s testing this by swapping tissues between young and older mice to find out more about these changes and how they might help us manage age-related health problems better.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | May 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $566,115 |
| NIH project number | 5U01AG086161-02 |
| Project ID | NIH-11083045 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing age-related health issues, particularly those affecting the heart and kidneys.
✕Less likely to help
Patients with acute or non-age-related conditions affecting the heart or kidneys may not benefit from this research.
What this research studies
This research investigates how aging alters the communication between the kidneys, adrenal glands, and heart, which can lead to conditions like cardiorenal syndrome. By transplanting adrenal and kidney tissues between young and aged mice, the study aims to uncover the mechanisms behind age-related dysfunction in these organs. The researchers will also explore how water loss and interorgan communication contribute to aging-related issues. Additionally, they will identify specific receptors involved in this process, which could lead to better management of age-associated health problems.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for age-related heart and kidney diseases.
How similar studies have gone: Other research has shown promising results in understanding interorgan communication and its impact on health, making this approach both relevant and potentially impactful.
Where this research is happening
-
Brown University
Providence, United States Active
Researchers
- Principal investigator: Tatar, Marc — Brown University
- Study coordinator: Tatar, Marc
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.