How aging affects cellular structures and responses
Official title: Molecular mechanisms of cellular response to age-associated chromatin changes
Funded at Baylor College of Medicine · NIH-11076630 · Data updated 2026-11-12
This study is looking at how changes in the material that makes up our chromosomes affect how our cells respond as we get older, using yeast to help us understand how these changes might help protect against age-related diseases and possibly even help us live longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $329,280 |
| NIH project number | 5R01AG081347-03 |
| Project ID | NIH-11076630 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related health issues or those interested in interventions that may promote healthy aging.
✕Less likely to help
Patients who are not experiencing age-related changes or diseases may not benefit from this research.
What this research studies
This research investigates how changes in chromatin, the material that makes up chromosomes, affect cellular responses as we age. By using yeast models that mimic the chromatin alterations seen in aged cells, the study aims to uncover the mechanisms behind a newly identified cellular response to chromatin stress. This response may help extend lifespan and combat age-related diseases by activating protective pathways in cells. The research will explore how this response interacts with other cellular stress pathways and metabolic changes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for delaying aging and treating age-related diseases.
How similar studies have gone: Previous research has shown promising results in understanding cellular responses to stress, suggesting potential for success in this area.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Dang, Weiwei — Baylor College of Medicine
- Study coordinator: Dang, Weiwei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.