How aging affects cancer development using engineered mouse models.
Impact of the aging niche on cancer phenotypes probed using mouse cancer models produced by somatic engineering.
['FUNDING_U01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10906067
This study is looking at how getting older affects cancer by using special mice that can develop cancer faster, helping researchers learn more about how age impacts cancer and how to create better treatments for older people.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10906067 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between aging and cancer by using advanced mouse models that have been genetically engineered to develop cancer more rapidly. By introducing specific mutations directly into the organs of aged mice, researchers can study how age-related changes in metabolism, immune function, and cellular damage contribute to cancer development. This approach allows for a more efficient examination of cancer characteristics and immune responses in older populations, which is crucial for developing better treatment strategies. The findings aim to enhance our understanding of cancer biology and improve interventions for older patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for developing cancer due to age-related factors.
Not a fit: Patients who are younger or do not have age-related cancer risks may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments specifically tailored for older patients, addressing a critical gap in current cancer therapies.
How similar studies have performed: Other research has shown promise in using genetically engineered mouse models to study cancer, indicating that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LOWE, SCOTT W. — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: LOWE, SCOTT W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Biology, Cancer Intervention