How aging affects cancer cells in the colon.
The role of the senescent microenvironment on cancer initiating cells in the colon.
This study looks at how aging affects the environment around colon cells and how older cells might help cancer develop, aiming to help older adults understand how their age could influence their risk of colorectal cancer.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10906917 on NIH RePORTER |
What this research studies
This research investigates how the aging process influences the environment around colon cells, particularly focusing on how senescent (aging) cells can promote the development of colorectal cancer. The study examines the interactions between these aging cells and cancer-initiating cells, aiming to understand the mechanisms that lead to cancer formation in older adults. By analyzing tissue samples and cellular behaviors, the research seeks to uncover the role of specific factors produced by senescent cells that may drive cancer progression. Patients may gain insights into how their age-related changes could impact their cancer risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those at high risk for colorectal cancer due to age or genetic factors.
Not a fit: Patients who are younger and do not have risk factors for colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating colorectal cancer in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of cellular aging in cancer development, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Grady, William Mallory — Fred Hutchinson Cancer Center
- Study coordinator: Grady, William Mallory
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.