How aging affects brain cell development and function
Aging dependent transformation of oligodendrocyte precursor cells
This study looks at how certain brain cells change as we get older and how these changes might affect brain health, with the hope of finding new ways to help people with age-related brain conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11076800 on NIH RePORTER |
What this research studies
This research investigates the role of oligodendrocyte precursor cells (OPCs) in the aging brain, focusing on how these cells change with age and their impact on neural signaling and plasticity. The study employs advanced imaging techniques to observe OPC behavior and their interactions with other glial cells in the brain. By understanding these changes, the research aims to uncover potential therapeutic targets for age-related neurological conditions. Patients may benefit from insights into how aging affects brain health and the potential for new treatments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include older adults experiencing cognitive decline or neurological conditions related to aging.
Not a fit: Patients with acute neurological injuries or those not affected by age-related changes may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing brain health and function in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of glial cells in brain health, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Bergles, Dwight E — Johns Hopkins University
- Study coordinator: Bergles, Dwight E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.