How aging affects bone-resorbing cells and bone health
The impact of age-related changes in osteoclast function on the skeleton
This study is looking at how aging affects the cells that break down bone, to help find new ways to prevent bone loss and encourage new bone growth, which could be really helpful for people with osteoporosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11078811 on NIH RePORTER |
What this research studies
This research investigates how age-related changes in osteoclast function impact bone health, particularly focusing on the balance between bone resorption and formation. The study aims to understand the functional diversity of osteoclasts, which are cells responsible for breaking down bone, and how their activity shifts with age. By exploring the mechanisms behind these changes, the research seeks to identify new treatment strategies that can reduce bone loss while promoting new bone formation, potentially leading to better management of osteoporosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related bone loss or those at risk for osteoporosis.
Not a fit: Patients who are younger than 21 or those without age-related bone health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that prevent osteoporosis-related fractures and improve bone health in older adults.
How similar studies have performed: Previous research has shown promising results in understanding osteoclast function and its implications for bone health, indicating that this approach has potential for success.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Weivoda, Megan M — Mayo Clinic Rochester
- Study coordinator: Weivoda, Megan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.