How aging affects bone cell responses to mechanical stress
Aging Effects on Mechanoregulation of Osteocytes using Multiscale Multiphysics
['FUNDING_R15'] · UNIVERSITY OF MISSOURI KANSAS CITY · NIH-10795452
This study is looking at how getting older affects bone cells and their ability to handle physical stress, and it's designed for students and researchers who want to learn more about keeping our bones healthy as we age.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MISSOURI KANSAS CITY (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-10795452 on ClinicalTrials.gov |
What this research studies
This research investigates how aging impacts the ability of bone cells, specifically osteocytes, to respond to mechanical loading. By using advanced computer modeling and 3D printing techniques, the study aims to create detailed models that simulate how these cells react to physical stress over time. The research will involve both undergraduate and graduate students working alongside experienced researchers to explore the biological pathways activated in osteocytes due to mechanical strain. The ultimate goal is to understand the mechanisms behind bone health and formation as we age.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for bone density loss or osteoporosis.
Not a fit: Patients who are younger and have no risk factors for bone health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for maintaining bone health and preventing osteoporosis in aging populations.
How similar studies have performed: Previous research has shown promising results in understanding bone mechanobiology, making this approach both relevant and potentially impactful.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF MISSOURI KANSAS CITY — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GANESH, THIAGARAJAN — UNIVERSITY OF MISSOURI KANSAS CITY
- Study coordinator: GANESH, THIAGARAJAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.