How aging affects blood vessel function in women
Mechanisms of Vascular Dysfunction with Advancing Reproductive Age
This study is looking at how changes in hormones and ovarian function as women age, especially during early menopause, affect the health of their blood vessels, with the goal of finding ways to help improve blood flow and overall vascular health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10595514 on NIH RePORTER |
What this research studies
This research investigates how the loss of ovarian function and changes in sex hormones with aging impact blood vessel health in women. It focuses on understanding the mechanisms behind impaired endothelial function, particularly during the early stages of menopause. The study will explore the roles of specific hormones and receptors in regulating blood vessel dilation and function. By measuring blood vessel responses in women at different reproductive ages, the research aims to identify potential interventions to improve vascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who are premenopausal or in the early stages of menopause.
Not a fit: Patients who are postmenopausal or have significant cardiovascular diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for vascular dysfunction in aging women.
How similar studies have performed: Other research has shown promising results in understanding hormonal influences on vascular health, making this approach both relevant and potentially impactful.
Where this research is happening
Newark, UNITED STATES
- University of Delaware — Newark, United States (Active)
Researchers
- Principal investigator: Wenner, Megan M — University of Delaware
- Study coordinator: Wenner, Megan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.