How aging affects blood vessel function in the brain of healthy individuals and those with Alzheimer's disease
Changes in Cerebrovascular Function with Aging in Normal and AD Brain
This study is looking at how certain brain cells called astrocytes help control blood flow and protect the brain as we get older, especially in people with Alzheimer's disease, to better understand how these changes might affect thinking and memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10762961 on NIH RePORTER |
What this research studies
This research investigates the role of astrocytes, a type of brain cell, in regulating blood flow and maintaining the blood-brain barrier as people age, particularly in the context of Alzheimer's disease. By examining the interactions between astrocytic endfeet and blood vessels, the study aims to understand how aging and amyloid deposits impact cerebrovascular function. The researchers will utilize advanced imaging techniques and models to observe changes in blood flow and barrier integrity over time. This could provide insights into the mechanisms behind cognitive decline in aging and Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults, particularly those with early signs of cognitive decline or a diagnosis of Alzheimer's disease.
Not a fit: Patients with acute neurological conditions or those not experiencing cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving brain health and preventing cognitive decline in aging and Alzheimer's disease.
How similar studies have performed: Previous studies have shown that vascular health is crucial for brain function, and this research builds on those findings to explore new aspects of cerebrovascular aging and Alzheimer's disease.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Sontheimer, Harald W — University of Virginia
- Study coordinator: Sontheimer, Harald W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.