How aging affects blood vessel function and its link to dementia
Regulation of Flt 1 Splicing by Fibronectin and Integrin Signaling During Aging
['FUNDING_OTHER'] · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · NIH-10777172
This study is looking at how aging affects blood vessels and their role in the risk of developing dementia, focusing on a protein called fibronectin, and it aims to help people understand how changes in blood flow to the brain might impact memory and thinking as we get older.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CONNECTICUT SCH OF MED/DNT (nih funded) |
| Locations | 1 site (FARMINGTON, UNITED STATES) |
| Trial ID | NIH-10777172 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between aging, blood vessel function, and the risk of developing dementia. It focuses on how a protein called fibronectin and its interaction with specific cell receptors may lead to changes in blood vessel structure and function as people age. By understanding these molecular mechanisms, the research aims to uncover how reduced blood flow in the brain contributes to cognitive decline. Patients may be involved in studies that explore these biological processes and their implications for dementia.
Who could benefit from this research
Good fit: Ideal candidates for participation are adults aged 21 and older, particularly those at risk for cognitive impairment or dementia.
Not a fit: Patients who are younger than 21 or do not have any risk factors for cognitive impairment or dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating dementia by improving blood vessel health in aging individuals.
How similar studies have performed: Other research has shown promising results in understanding the role of vascular health in cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
FARMINGTON, UNITED STATES
- UNIVERSITY OF CONNECTICUT SCH OF MED/DNT — FARMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MURPHY, PATRICK ANDRIES — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
- Study coordinator: MURPHY, PATRICK ANDRIES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia