How aging affects blood vessel function and its link to dementia
Official title: Regulation of Flt 1 Splicing by Fibronectin and Integrin Signaling During Aging
Funded at University of Connecticut Sch of Med/dnt · NIH-10777172 · Data updated 2026-11-12
This study is looking at how aging affects blood vessels and their role in the risk of developing dementia, focusing on a protein called fibronectin, and it aims to help people understand how changes in blood flow to the brain might impact memory and thinking as we get older.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,583,383 |
| NIH project number | 1RF1NS135026-01 |
| Project ID | NIH-10777172 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are adults aged 21 and older, particularly those at risk for cognitive impairment or dementia.
✕Less likely to help
Patients who are younger than 21 or do not have any risk factors for cognitive impairment or dementia may not benefit from this research.
What this research studies
This research investigates the relationship between aging, blood vessel function, and the risk of developing dementia. It focuses on how a protein called fibronectin and its interaction with specific cell receptors may lead to changes in blood vessel structure and function as people age. By understanding these molecular mechanisms, the research aims to uncover how reduced blood flow in the brain contributes to cognitive decline. Patients may be involved in studies that explore these biological processes and their implications for dementia.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating dementia by improving blood vessel health in aging individuals.
How similar studies have gone: Other research has shown promising results in understanding the role of vascular health in cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Murphy, Patrick Andries — University of Connecticut Sch of Med/dnt
- Study coordinator: Murphy, Patrick Andries
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.