How aging affects blood stem cells and their role in acute myeloid leukemia
Aging-related hematopoietic stem cell intrinsic and microenvironmental signals in AML transformation
This study is looking at how getting older affects blood stem cells and their surroundings, which might help explain how some people develop acute myeloid leukemia (AML), and it involves analyzing blood and bone marrow from patients to learn more about these changes.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10935667 on NIH RePORTER |
What this research studies
This research investigates how aging impacts blood stem cells and their environment, contributing to the development of acute myeloid leukemia (AML). It focuses on understanding the changes in these stem cells and the surrounding niche that may lead to the transformation of pre-leukemic conditions into AML. By utilizing advanced genetic tools and single-cell technology, the research aims to uncover the mechanisms that allow mutated blood stem cells to thrive and eventually cause leukemia. Patients may be involved in studies that analyze their blood and bone marrow to better understand these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have pre-leukemic conditions such as age-related clonal hematopoiesis, myelodysplastic syndromes, or myeloproliferative neoplasms.
Not a fit: Patients who are younger and do not have any pre-leukemic conditions or acute myeloid leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating acute myeloid leukemia in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of aging in blood disorders, making this approach both relevant and potentially impactful.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Kousteni, Stavroula — Columbia University Health Sciences
- Study coordinator: Kousteni, Stavroula
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.