How aging affects artery stiffness and blood pressure in older adults
Sympathetic Regulation of Large Artery Stiffness in Humans with Age-Related Isolated Systolic Hypertension
This study is looking at how the nerves that control your body's stress response affect the stiffness of large arteries in older adults with high blood pressure, and it hopes to find ways to make those arteries more flexible to help improve heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10843959 on NIH RePORTER |
What this research studies
This research investigates how sympathetic nerve activity influences the stiffness of large arteries in older adults with isolated systolic hypertension. It aims to understand the relationship between age-related increases in artery stiffness and the rise in blood pressure, which can lead to cardiovascular diseases. The study will assess the effectiveness of chronic inhibition of sympathetic nerve activity to reduce artery stiffness and improve blood flow dynamics. By examining these factors, the research seeks to provide insights into potential interventions for older adults at risk of cardiovascular issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with isolated systolic hypertension.
Not a fit: Patients who are younger than 21 or do not have isolated systolic hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce artery stiffness and improve cardiovascular health in older adults.
How similar studies have performed: Previous research has shown that targeting sympathetic nerve activity can lead to improvements in cardiovascular health, suggesting this approach may be promising.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Pierce, Gary L. — University of Iowa
- Study coordinator: Pierce, Gary L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.