How age affects the exhaustion of immune cells in response to infections
Regulation of CD8+ T cell exhaustion by let-7/Lin28b in different stages of life
This study is looking at how a special type of immune cell, called CD8+ T cells, can get tired out during long-lasting infections and how this changes as we get older, with the goal of finding better ways to help our immune system fight off these infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10979178 on NIH RePORTER |
What this research studies
This research investigates how CD8+ T cells, a type of immune cell, become exhausted during chronic infections and how this process varies with age. The study focuses on understanding the developmental origins of these cells and their responses to prolonged antigen exposure. By comparing T cells from neonates and adults, the researchers aim to identify factors that influence T cell function and exhaustion. Innovative techniques will be employed to explore the role of specific proteins in this process, potentially leading to improved immunotherapy strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old who are experiencing acute infections or are undergoing adoptive T cell therapies.
Not a fit: Patients who are over 21 years old or those not undergoing T cell-based therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies for infections and cancers by enhancing T cell function.
How similar studies have performed: Previous research has shown that understanding the mechanisms of T cell exhaustion can lead to advancements in immunotherapy, indicating that this approach has potential for success.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Maymi, Viviana Isabel — Cornell University
- Study coordinator: Maymi, Viviana Isabel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.