How adenoviruses affect cellular RNA processing
Official title: Adenovirus regulation of cellular RNA binding proteins
Funded at Children's Hosp of Philadelphia · NIH-11102157 · Data updated 2026-11-12
This study looks at how adenoviruses trick our body's proteins to help them multiply and avoid being attacked by our immune system, which could help us find better ways to fight these infections in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | January 14, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $729,006 |
| NIH project number | 1R01AI189552-01 |
| Project ID | NIH-11102157 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with adenovirus infections or those at risk of such infections.
✕Less likely to help
Patients with non-viral respiratory infections or those not affected by adenoviruses may not benefit from this research.
What this research studies
This research investigates how adenoviruses manipulate host RNA binding proteins to enhance their own replication while evading the host's immune response. By studying the interactions between adenoviruses and cellular RNA processing machinery, the research aims to uncover the mechanisms that allow these viruses to redirect cellular functions for their benefit. The approach includes advanced techniques like mass spectrometry and RNA binding region identification to analyze changes in protein modifications and interactions during infection. This could lead to a better understanding of viral infections and potential antiviral strategies.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral therapies targeting adenovirus infections.
How similar studies have gone: Previous research has shown success in understanding viral manipulation of host cellular processes, indicating potential for breakthroughs in antiviral therapies.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Weitzman, Matthew D. — Children's Hosp of Philadelphia
- Study coordinator: Weitzman, Matthew D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.