How adenovirus hijacks the proteins that control your cells' RNA
Adenovirus regulation of cellular RNA binding proteins
['FUNDING_R01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-11258997
Researchers are looking at how adenovirus changes the proteins that manage RNA inside infected cells to learn how the virus takes over cells.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11258997 on ClinicalTrials.gov |
What this research studies
This project examines how adenovirus redirects cellular RNA-binding proteins to change RNA splicing, transport, and translation during infection. Scientists will examine infected cell nuclei over time and use mass spectrometry proteomics and RNA Binding Region Identification (RBR-ID) to track changes in protein modifications and RNA interactions. The team is focusing on loss of arginine methylation and decreased RNA binding observed with adenovirus serotype 5, mapping which host proteins are altered and when. Findings come from laboratory cell models and detailed protein and RNA interaction assays.
Who could benefit from this research
Good fit: People with recent adenovirus infection or individuals willing to donate respiratory or blood samples could potentially contribute samples for related parts of this research.
Not a fit: This is laboratory-focused research and will not provide direct treatment or immediate clinical benefit to people currently sick with adenovirus.
Why it matters
Potential benefit: If successful, the work could reveal new targets for antiviral drugs or biomarkers that help prevent or treat adenovirus infections.
How similar studies have performed: Proteomics and RNA-binding studies have uncovered viral control of host proteins for other viruses, but applying these precise methods to adenovirus is more recent and still developing.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEITZMAN, MATTHEW D. — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: WEITZMAN, MATTHEW D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adenoviridae Infections, Adenovirus Infections