How adding arginine to proteins affects stress responses and metabolism
Oxidative stress response and metabolic reprogramming by protein posttranslational arginylation
This study is looking at how a special process that adds an extra building block to proteins might help our cells deal with stress from things like aging and diseases, and it could lead to new ways to understand and treat these health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10675479 on NIH RePORTER |
What this research studies
This research investigates the role of posttranslational arginylation, a process where an extra arginine is added to proteins, in the cellular response to oxidative stress and metabolic changes. By focusing on the enzyme Arginyltransferase1 (ATE1), the study aims to uncover how arginylation influences the body's ability to cope with oxidative stress, which is linked to various diseases including cancer and aging-related conditions. The researchers are developing new methods to identify the proteins affected by arginylation, which could lead to better understanding and potential interventions for diseases caused by oxidative stress. This work is crucial for developing strategies to prevent or treat conditions associated with metabolic dysregulation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions linked to oxidative stress, such as cancer patients or those experiencing age-related health issues.
Not a fit: Patients with conditions unrelated to oxidative stress or metabolic dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to oxidative stress, such as cancer and cardiovascular disorders.
How similar studies have performed: While the specific approach of targeting arginylation is relatively novel, previous research has shown that understanding oxidative stress responses can lead to significant advancements in treatment strategies.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Zhang, Fangliang — University of Miami School of Medicine
- Study coordinator: Zhang, Fangliang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.