How activated platelets contribute to lung blood vessel changes in pulmonary hypertension
Complement-Driven Platelet Activation in Pulmonary Vascular Remodeling and Pulmonary Hypertension
This study is looking at how certain blood cells called platelets, which can get activated by the immune system, affect blood vessels in the lungs of people with pulmonary hypertension, and it aims to find out how this process contributes to the condition so we can better understand and treat it.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10911069 on NIH RePORTER |
What this research studies
This research investigates how activated platelets, influenced by the complement system, contribute to changes in blood vessels in the lungs, particularly in pulmonary hypertension (PH). By using both animal models and human samples, the study aims to understand the mechanisms behind platelet activation and its role in promoting inflammation and vascular remodeling. The researchers will employ innovative genetic and pharmacologic techniques to explore how complement proteins activate platelets and lead to endothelial dysfunction, which is a key factor in the progression of PH.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary hypertension or those at risk for developing this condition.
Not a fit: Patients with pulmonary hypertension caused by non-inflammatory factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating pulmonary hypertension by targeting platelet activation.
How similar studies have performed: Previous studies have shown that targeting platelet activation can have beneficial effects in other inflammatory conditions, suggesting potential success for this approach in pulmonary hypertension.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Delaney, Cassidy a — University of Colorado Denver
- Study coordinator: Delaney, Cassidy a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.