How acetaminophen affects brain development in unborn babies
Effects of acetaminophen on prenatal brain development: an organoid model
['FUNDING_R21'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10684055
This study is looking into how taking acetaminophen while pregnant might affect the brain development of babies, especially during the important later stages of pregnancy, to help expectant moms understand any potential risks.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10684055 on ClinicalTrials.gov |
What this research studies
This research investigates the potential negative effects of acetaminophen, a common pain reliever, on the brain development of fetuses. Using advanced human brain organoid models, the study aims to understand how acetaminophen exposure during pregnancy may disrupt critical processes in fetal brain development. The researchers will explore specific cellular and molecular pathways that could be affected by acetaminophen, particularly during the crucial second and third trimesters of pregnancy. By identifying these mechanisms, the research seeks to provide insights into the risks associated with acetaminophen use during pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals who have used or are considering using acetaminophen for pain or fever relief.
Not a fit: Patients who are not pregnant or those who have not used acetaminophen during pregnancy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better guidelines for the safe use of acetaminophen during pregnancy, potentially reducing the risk of developmental disorders in children.
How similar studies have performed: While there is growing evidence suggesting risks associated with acetaminophen use during pregnancy, this specific approach using brain organoids is relatively novel and has not been extensively tested.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: IAKOUCHEVA, LILIA M — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: IAKOUCHEVA, LILIA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.