How ABO and H blood groups shape immune reactions
Project-005
This project explores how ABO and H blood types affect immune responses to help people who need transfusions or have blood-type related immune problems.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11135400 on NIH RePORTER |
What this research studies
If you join, researchers may ask for small blood samples and medical history to link your blood type with immune markers. Labs will use blood tests and modern molecular methods to map ABH antigens and the antibodies or immune cells that react to them. Multiple teams will combine patient samples with laboratory experiments to test new laboratory and computational approaches. The goal is to turn those findings into clearer guidance for safer transfusions and better blood matching.
Who could benefit from this research
Good fit: Ideal candidates would include people who donate or receive blood, those with unusual ABO/H blood types, or individuals with a history of transfusion reactions or blood-type antibodies.
Not a fit: Patients with health issues unrelated to blood groups or those seeking immediate clinical treatment are unlikely to benefit directly from participation.
Why it matters
Potential benefit: If successful, this work could reduce transfusion reactions and improve matching for transfusions and transplants.
How similar studies have performed: Research on ABO blood groups and transfusion immunology has a long history with important successes, but the specific novel laboratory and computational approaches proposed here are more exploratory.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Stowell, Sean R — Brigham and Women's Hospital
- Study coordinator: Stowell, Sean R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.