How abnormal particles from human islets affect type 1 diabetes progression
Official title: Abnormal Extracellular Vesicles and Particles from Human Islets Impact T1D progression
Funded at Weill Medical Coll of Cornell Univ · NIH-10911368 · Data updated 2026-11-12
This study is looking at tiny particles released by insulin-producing cells in the pancreas to see how they might affect the progression of type 1 diabetes, with the hope of finding new ways to help manage the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 21, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $678,579 |
| NIH project number | 5R01DK137517-02 |
| Project ID | NIH-10911368 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with type 1 diabetes, as well as those at risk of developing the condition.
✕Less likely to help
Patients with type 2 diabetes or other forms of diabetes unrelated to the mechanisms being studied may not benefit from this research.
What this research studies
This research investigates the role of abnormal extracellular vesicles and particles (EVPs) secreted by human islets in the progression of type 1 diabetes (T1D). By analyzing these EVPs, the research aims to understand how they impact the function and survival of insulin-producing beta cells and their interaction with immune cells. The study utilizes human samples, including islets from healthy and T1D donors, to identify specific proteins associated with these EVPs. This approach seeks to provide insights into the mechanisms driving T1D and potentially identify new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating type 1 diabetes by targeting the mechanisms involved in beta cell dysfunction.
How similar studies have gone: While some studies have explored EVPs in mouse models, this research is novel as it focuses specifically on human samples and their implications for T1D progression.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Chen, Shuibing — Weill Medical Coll of Cornell Univ
- Study coordinator: Chen, Shuibing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.