How abnormal glycogen affects brain metabolism in aging and Alzheimer's disease
Aberrant Glycogen Modulates Cerebral Glucose Metabolism in Aging and Alzheimer's Disease
This study is looking at how unusual sugar deposits in the brain might affect how our brains use energy as we age and deal with Alzheimer's disease, and it hopes to find a way to clear these deposits to help improve brain health and thinking skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10821457 on NIH RePORTER |
What this research studies
This research investigates the role of abnormal glycogen aggregates in the brain and how they influence glucose metabolism, particularly in the context of aging and Alzheimer's disease. The study aims to understand the molecular mechanisms behind the formation of these glycogen aggregates and their impact on brain function. By examining both human and animal models, the researchers will explore how these metabolic changes contribute to cognitive decline. Additionally, they will evaluate a potential therapy that targets and clears these abnormal glycogen deposits to improve brain metabolism and cognitive function.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
Not a fit: Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve brain metabolism and cognitive function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding metabolic changes in Alzheimer's disease, but this specific approach targeting abnormal glycogen is relatively novel.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Sun, Ramon C. — University of Florida
- Study coordinator: Sun, Ramon C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.