How a ZFTA-RELA gene fusion drives some childhood ependymomas and where new drugs might target it
Discovering the mechanisms underlying oncogenesis by ZFTA-RELA and pinpointing therapeutic targets.
Looking at how a specific gene fusion causes aggressive childhood ependymoma so researchers can find new, targeted treatments for kids with ZFTA-driven tumors.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11192829 on NIH RePORTER |
What this research studies
From a patient's point of view, researchers are studying a common gene fusion called ZFTA-RELA that drives a form of pediatric brain tumor (ependymoma). They will use lab-grown cells and mouse models plus molecular tools like CRISPR screens to find which parts of the fusion protein and its partners are essential for tumor growth. The team will map where the fusion binds DNA, study how it forms dynamic nuclear condensates, and test which interaction partners might be druggable. The goal is to turn those lab findings into candidate targets that could eventually lead to new medicines.
Who could benefit from this research
Good fit: Children with cortical ependymoma confirmed to carry a ZFTA-RELA (ZRFUS) gene fusion, especially those with recurrent or treatment-resistant disease.
Not a fit: People whose tumors lack ZFTA fusions, patients with other brain tumor types, or unrelated adult cancers are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could identify new targeted treatment options for children with ZFTA-RELA driven ependymoma beyond surgery and radiation.
How similar studies have performed: Preclinical studies and mouse models have shown ZFTA-RELA can drive tumors and form nuclear condensates, but targeted therapies against this fusion have not yet been proven in patients.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Mack, Stephen C — St. Jude Children's Research Hospital
- Study coordinator: Mack, Stephen C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.