How a virus modifies proteins to evade the immune response.
Antiviral responses of host mediated S-nitrosylation of viral proteins.
This study is looking at how the human cytomegalovirus (HCMV) changes its proteins to escape the body's defenses, with the hope of finding new ways to treat infections caused by this virus, which currently has no vaccine or cure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-11035238 on NIH RePORTER |
What this research studies
This research investigates how the human cytomegalovirus (HCMV) modifies its proteins through a process called S-nitrosylation to evade the host's antiviral responses. The study aims to understand the mechanisms behind these modifications and their effects on HCMV replication. By examining the interaction between HCMV proteins and the host's immune system, the research seeks to uncover potential therapeutic targets for treating infections caused by this virus. Patients may benefit from insights that could lead to new treatments for HCMV, especially since there is currently no vaccine or cure available.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are infected with human cytomegalovirus, particularly those with compromised immune systems.
Not a fit: Patients who are not infected with HCMV or those with fully functioning immune systems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies for HCMV infections.
How similar studies have performed: Other research has shown promise in understanding viral evasion strategies, making this approach both relevant and potentially impactful.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Murphy, Eain a — Upstate Medical University
- Study coordinator: Murphy, Eain a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.