How a virus interacts with blood stem cells to control its dormant state
Virus-host interactions regulating innate signaling for human cytomegalovirus latency
This study is looking at how the human cytomegalovirus (HCMV) hides in certain blood cells and stays inactive, which can help us find better ways to manage the virus in people, especially those getting organ transplants or stem cell treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-11014417 on NIH RePORTER |
What this research studies
This research investigates how human cytomegalovirus (HCMV) interacts with CD34+ hematopoietic progenitor cells to establish and maintain its dormant state, known as latency. By using advanced laboratory models, the study aims to uncover the molecular mechanisms that allow the virus to evade the immune system and reactivate when conditions are favorable. The research focuses on specific viral genes and their interactions with host proteins that regulate important signaling pathways. Understanding these interactions could lead to better strategies for managing HCMV in patients, especially those undergoing organ transplants or stem cell therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing solid organ or hematopoietic stem cell transplantation who are at risk for HCMV infection.
Not a fit: Patients who are not undergoing transplantation or who do not have HCMV-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients at risk of HCMV-related complications after transplants.
How similar studies have performed: While the specific approach of this research is novel, there have been successful studies exploring virus-host interactions in other contexts.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Goodrum, Felicia D — University of Arizona
- Study coordinator: Goodrum, Felicia D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.