How a virus contributes to cancer development in low-oxygen environments

Who could benefit from this research

What this research studies

This research investigates how the Kaposi's sarcoma-associated herpesvirus (KSHV) influences the development of Kaposi's sarcoma (KS) in areas of the body with low oxygen levels. It focuses on the role of hypoxia, a condition common in solid tumors, and how KSHV may exploit this environment to promote the transformation of mesenchymal stem cells into cancerous cells. By studying the interactions between KSHV and the body's cells, the research aims to uncover the mechanisms that lead to tumor formation and progression in KS. This could provide insights into potential therapeutic targets for treating this type of cancer.

Why it matters

Where this research is happening

• University of Pennsylvania
  Philadelphia, United States Active

Researchers

• Principal investigator: Yuan, Yan — University of Pennsylvania
• Study coordinator: Yuan, Yan

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.