How a virus changes fat metabolism in human cells
Mechanisms of Human Cytomegalovirus Reprogramming of Lipid Metabolism
['FUNDING_R01'] · UNIVERSITY OF ARIZONA · NIH-10873747
This study is looking at how the human cytomegalovirus (HCMV) changes the way our cells handle fats, which helps the virus survive and grow, and it could lead to new ways to treat infections caused by this virus.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-10873747 on ClinicalTrials.gov |
What this research studies
This research investigates how human cytomegalovirus (HCMV) alters the metabolism of lipids in infected human cells. By focusing on the interactions between the virus and the host's lipid synthesis processes, the study aims to uncover the mechanisms that allow HCMV to thrive by manipulating the host's metabolic pathways. The researchers are particularly interested in a group of unique lipids that are produced during infection, which may play critical roles in the virus's life cycle. Understanding these processes could lead to new insights into treating infections caused by HCMV.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are immunocompromised or newborns at risk of congenital disabilities due to HCMV.
Not a fit: Patients who are not infected with HCMV or who have a robust immune system may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapeutic strategies for managing HCMV infections, particularly in immunocompromised patients.
How similar studies have performed: While the specific mechanisms of HCMV-induced lipid metabolism are not extensively studied, similar research approaches have shown promise in understanding viral interactions with host metabolism.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PURDY, JOHN GERARD — UNIVERSITY OF ARIZONA
- Study coordinator: PURDY, JOHN GERARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: CMV infection