How a virus alters tumor suppressor functions in certain cancers
Tumor suppressor reprogramming by EBV through post-translational modification
This study is looking at how the Epstein-Barr virus affects certain proteins that help prevent cancer in people with HIV who have B-cell lymphomas, with the hope of finding new ways to treat these cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10904818 on NIH RePORTER |
What this research studies
This research investigates how the Epstein-Barr virus (EBV) affects tumor suppressor proteins in B-cell lymphomas, particularly in patients with HIV. By examining the interactions between EBV and the cellular mechanisms that regulate cell growth and survival, the study aims to understand how these viral infections contribute to cancer development. The approach includes laboratory experiments to analyze the behavior of B-cells infected with EBV and the role of specific viral proteins in altering normal cellular functions. Patients may benefit from insights that could lead to new therapeutic strategies for managing EBV-related cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV-positive individuals who are at risk for developing B-cell lymphomas due to opportunistic infections.
Not a fit: Patients who do not have HIV or are not at risk for B-cell lymphomas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for B-cell lymphomas in HIV-positive patients.
How similar studies have performed: Previous research has shown that understanding viral interactions with tumor suppressors can lead to significant advancements in cancer treatment, indicating a promising avenue for this study.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Robertson, Erle S. — University of Pennsylvania
- Study coordinator: Robertson, Erle S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.