How a virus affects cell movement and structure
Nuclear rotation and cellular reorganization during Cytomegalovirus infection
This study looks at how the Human Cytomegalovirus changes the way infected cells move and work, which could help us find better ways to treat people who are more at risk for HCMV infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11045604 on NIH RePORTER |
What this research studies
This research investigates how Human Cytomegalovirus (HCMV) alters the structure and movement of infected cells. By using advanced imaging techniques, the study observes the dynamic behavior of a specific cellular structure called the Assembly Compartment, which is crucial for the virus's replication. The researchers aim to understand how HCMV rotates the nucleus of infected cells and how this affects their motility and overall function. This knowledge could lead to better strategies for managing HCMV infections, especially in vulnerable populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with compromised immune systems, such as those with AIDS or transplant recipients, as well as patients affected by congenital birth defects caused by HCMV.
Not a fit: Patients who are not infected with HCMV or do not have related health complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or preventive measures for HCMV-related health issues, particularly in immunocompromised patients.
How similar studies have performed: Previous research has shown promising results in understanding viral behavior and its impact on cellular processes, indicating that this approach could yield valuable insights.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Walsh, Derek — Northwestern University at Chicago
- Study coordinator: Walsh, Derek
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.