How a virus affects cancer cell growth and metabolism
Deamidation-mediated metabolic reprogramming by KSHV in cell proliferation and tumorigenesis
This study is looking at how a virus linked to a type of cancer changes how our cells use energy, which might help the virus avoid our immune system and make cancer grow faster, and the findings could lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10632091 on NIH RePORTER |
What this research studies
This research investigates how the Human Kaposi’s Sarcoma-associated Herpesvirus (KSHV) influences cancer development by altering cellular metabolism. The study focuses on a specific protein modification process called deamidation, which KSHV uses to evade the immune response and promote cancer cell proliferation. By examining the role of glutamine amidotransferases in this process, researchers aim to uncover the molecular mechanisms that lead to tumor formation. Patients may benefit from insights gained into how KSHV contributes to cancer, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers associated with KSHV, such as Kaposi's sarcoma.
Not a fit: Patients with cancers not related to KSHV or those without any viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target the metabolic changes induced by KSHV in cancer cells.
How similar studies have performed: Other research has shown success in understanding viral mechanisms in cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Zhao, Jun — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Zhao, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.