How a tumor suppressor protein affects cancer signaling pathways
Inhibition of the Wnt Receptor Complex by the Tumor Suppressor Adenomatous Polyposis Coli
This study is looking at how a protein called APC helps stop the growth of colorectal cancer by blocking a key signaling pathway, and it's aimed at finding new treatment options for patients whose cancer is linked to changes in the APC gene.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-10869954 on NIH RePORTER |
What this research studies
This research investigates the role of the tumor suppressor protein Adenomatous Polyposis Coli (APC) in inhibiting the Wnt signaling pathway, which is crucial for the development of colorectal cancer. By understanding how APC regulates the Wnt receptor complex, the researchers aim to find new ways to target colorectal cancers that have mutations in the APC gene. The study employs various laboratory techniques to explore the mechanisms of APC's action and its potential therapeutic implications for patients with APC mutant colorectal cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer that has mutations in the APC gene.
Not a fit: Patients with colorectal cancer that does not involve APC mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients with colorectal cancer caused by APC mutations.
How similar studies have performed: Previous research has shown promising results in targeting Wnt signaling pathways in cancer, indicating that this approach may be effective.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Ahmed, Yasmath — Dartmouth College
- Study coordinator: Ahmed, Yasmath
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.