How a toxin from Mycoplasma pneumoniae causes airway inflammation in children
Unique ADP-ribosylating and vacuolating properties of Mycoplasma pneumoniae CARDS toxin trigger airway inflammation and disease progression
This study is looking at how a toxin from a germ that causes pneumonia in kids affects their lungs and causes breathing problems, so we can better understand how to help those with severe respiratory issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10578740 on NIH RePORTER |
What this research studies
This research investigates the effects of a specific toxin produced by Mycoplasma pneumoniae, which is a leading cause of pneumonia in children. The study focuses on how this toxin triggers inflammation and damage in the airways, leading to respiratory issues. By examining the mechanisms of this toxin, researchers aim to understand its role in severe respiratory disorders and how it activates inflammatory responses in the body. The research utilizes animal models to observe the effects of the toxin on lung health and inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have experienced pneumonia or related respiratory issues.
Not a fit: Patients who are older than 11 years or do not have a history of pneumonia or respiratory disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for respiratory diseases caused by Mycoplasma pneumoniae in children.
How similar studies have performed: Previous research has shown that understanding the mechanisms of respiratory pathogens can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Kannan, Thirumalai Rengasamy — University of Texas Hlth Science Center
- Study coordinator: Kannan, Thirumalai Rengasamy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.