How a tiny chemical tag called sulfotyrosine affects infections and blood clotting
Sulfotyrosine, an essential determinant for diverse protein-protein interactions
Researchers are looking at how a small chemical change called sulfotyrosine changes how viruses like HIV enter cells and how molecules that affect blood clotting work, to help people with infections or clotting problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11260151 on NIH RePORTER |
What this research studies
This project focuses on a chemical tag on proteins called sulfotyrosine that can change how proteins stick together and signal. The team will find and map receptors that bind sulfated peptides, analyze the molecular interfaces where binding happens, and develop ways to produce and test new sulfated molecules. Work will combine biochemical experiments, structural analysis, and cell-based assays relevant to viral entry and clotting biology. Findings aim to connect basic molecular details to potential therapeutic molecules.
Who could benefit from this research
Good fit: People living with HIV or those with blood-clotting disorders would be the most likely future beneficiaries or candidates for downstream trials based on this research.
Not a fit: Patients without infectious diseases or clotting issues are unlikely to see direct benefit from this laboratory-focused work in the near term.
Why it matters
Potential benefit: If successful, the work could point to new ways to block HIV entry or to design sulfated peptides that treat blood-clotting problems.
How similar studies have performed: Prior studies have shown sulfotyrosine plays a key role in HIV entry and that some sulfated peptides can affect clotting, so this builds on promising but still incomplete early findings.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Ronald, Pamela C — University of California at Davis
- Study coordinator: Ronald, Pamela C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.