How a specific serotonin receptor affects cocaine addiction
Influence of 5-HT1b Activation on the Abuse Related Effects of Cocaine
This study is looking at how a specific brain receptor might change the way people behave and make decisions when using cocaine, and it’s for individuals who are dealing with cocaine addiction to help find better treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10457811 on NIH RePORTER |
What this research studies
This research investigates the role of the 5-HT1b receptor in cocaine addiction by examining how activating this receptor may influence the effects of cocaine on behavior and decision-making. The study will involve a double-blind methodology, where participants will receive either a medication that activates the 5-HT1b receptor or a placebo, allowing researchers to assess the impact on cocaine-related behaviors. By translating findings from preclinical models to human subjects, the research aims to identify neurobiological circuits involved in cocaine use disorder and guide future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are non-treatment seeking individuals who meet the diagnostic criteria for cocaine use disorder.
Not a fit: Patients who are actively seeking treatment for cocaine addiction or those with other substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for individuals struggling with cocaine addiction.
How similar studies have performed: Previous research has shown promising results in preclinical models regarding the role of the 5-HT1b receptor in cocaine addiction, but this approach is still being tested in clinical populations.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Stoops, William Walton — University of Kentucky
- Study coordinator: Stoops, William Walton
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.