How a specific RNA modification affects DNA repair in cancer cells
N6-methyladenosine (m6A) Interplays with RNA and DNA Damage to Regulate DNA Repair
This study is looking at how a specific change in RNA, called m6A, affects how cancer cells handle DNA damage and respond to treatments, with the goal of finding new ways to improve cancer care.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-10804692 on NIH RePORTER |
What this research studies
This research investigates the role of N6-methyladenosine (m6A), a common modification in RNA, in the processes of DNA damage and repair in cancer cells. The study aims to understand how changes in m6A profiles can influence cancer progression and resistance to chemotherapy. By examining the effects of oxidative damage on RNA and DNA, researchers will explore how m6A interacts with these processes to potentially identify new drug targets and biomarkers for cancer treatment. The research involves laboratory experiments using cancer cell lines to analyze m6A profiles and their modulation in response to DNA damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancer, particularly those experiencing treatment resistance.
Not a fit: Patients with non-malignant conditions or those not diagnosed with cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for cancer therapy by identifying novel drug targets and biomarkers.
How similar studies have performed: Other research has shown promising results in understanding RNA modifications and their roles in cancer, suggesting this approach has potential for success.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: Liu, Yuan — Florida International University
- Study coordinator: Liu, Yuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.