How a specific RNA modification affects DNA repair in cancer cells
Official title: N6-methyladenosine (m6A) Interplays with RNA and DNA Damage to Regulate DNA Repair
Funded at Florida International University · NIH-10804692 · Data updated 2026-11-12
This study is looking at how a specific change in RNA, called m6A, affects how cancer cells handle DNA damage and respond to treatments, with the goal of finding new ways to improve cancer care.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project start | March 7, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $73,750 |
| NIH project number | 5R03ES035200-02 |
| Project ID | NIH-10804692 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cancer, particularly those experiencing treatment resistance.
✕Less likely to help
Patients with non-malignant conditions or those not diagnosed with cancer may not benefit from this research.
What this research studies
This research investigates the role of N6-methyladenosine (m6A), a common modification in RNA, in the processes of DNA damage and repair in cancer cells. The study aims to understand how changes in m6A profiles can influence cancer progression and resistance to chemotherapy. By examining the effects of oxidative damage on RNA and DNA, researchers will explore how m6A interacts with these processes to potentially identify new drug targets and biomarkers for cancer treatment. The research involves laboratory experiments using cancer cell lines to analyze m6A profiles and their modulation in response to DNA damage.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for cancer therapy by identifying novel drug targets and biomarkers.
How similar studies have gone: Other research has shown promising results in understanding RNA modifications and their roles in cancer, suggesting this approach has potential for success.
Where this research is happening
-
Florida International University
Miami, United States Active
Researchers
- Principal investigator: Liu, Yuan — Florida International University
- Study coordinator: Liu, Yuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.