How a specific receptor may protect against blood vessel problems in adults who were preterm infants exposed to high oxygen levels.
Protective role of CXCR7 in neonatal hyperoxia-induced systemic vascular dysfunction in adulthood
This study looks at how being exposed to high levels of oxygen as a preterm baby might affect blood vessel health later in life, and it’s exploring a specific receptor that could help reduce problems with stiff blood vessels, aiming to find new ways to prevent heart issues for those who were born early.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10899452 on NIH RePORTER |
What this research studies
This research investigates the long-term effects of high oxygen exposure in preterm infants and how it leads to vascular issues in adulthood. The study focuses on a specific receptor, CXCR7, and its role in reducing vascular stiffness caused by neonatal hyperoxia. By exploring the molecular mechanisms involved, the research aims to identify potential strategies to prevent cardiovascular complications in individuals who were preterm. Patients may benefit from insights that could lead to new treatments or preventive measures for vascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who were born preterm and may have experienced high oxygen exposure as infants.
Not a fit: Patients who were not born preterm or did not experience neonatal hyperoxia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cardiovascular diseases in adults who were preterm infants.
How similar studies have performed: While the specific approach of targeting CXCR7 in this context may be novel, similar studies have shown promise in understanding vascular complications related to neonatal care.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Benny, Merline — University of Miami School of Medicine
- Study coordinator: Benny, Merline
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.