How a specific receptor affects immune cells and healing in diabetes-related wounds
Official title: Role of pregnane x receptor activation on macrophage function and diabetic wound healing
Funded at Mississippi State University · NIH-10730438 · Data updated 2026-11-12
This study is looking at how a specific receptor in the body affects immune cells that help heal wounds, especially for people with diabetes, to find new ways to improve healing and prevent issues like foot ulcers.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mississippi State University NIH-funded |
| Lab location | 1 site (Mississippi State, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $439,500 |
| NIH project number | 1R15ES035527-01 |
| Project ID | NIH-10730438 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with type 1 diabetes who are at risk of developing diabetic foot ulcers.
✕Less likely to help
Patients without diabetes or those who do not have issues with wound healing may not benefit from this research.
What this research studies
This research investigates how the activation of the pregnane x receptor (PXR) influences the function of immune cells called macrophages, which are crucial for wound healing, particularly in patients with diabetes. The study aims to understand the mechanisms by which environmental factors and certain chemicals can alter macrophage behavior, potentially leading to complications like diabetic foot ulcers. By exploring these interactions, the research seeks to identify new therapeutic strategies to enhance wound healing in diabetic patients. The approach involves both laboratory experiments and analysis of macrophage responses to various stimuli.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetic foot ulcers, reducing the risk of complications such as limb amputation.
How similar studies have gone: Previous research has shown promising results in understanding macrophage function in wound healing, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mississippi State University
Mississippi State, United States Active
Researchers
- Principal investigator: Howell, George E — Mississippi State University
- Study coordinator: Howell, George E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.