How a specific receptor affects gut health and movement in the digestive system.
Official title: Regulation of intestinal epithelial barrier and motility by the LPA1 receptor in the enteric nervous system
Funded at Veterans Health Administration · NIH-11063276 · Data updated 2026-11-12
This study is looking at how a specific receptor in the gut affects digestive health, especially for military personnel, by exploring how stress and infections might lead to issues like irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), with the goal of finding ways to improve gut health and function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Decatur, UNITED STATES) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| NIH project number | 5I01BX006369-02 |
| Project ID | NIH-11063276 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are military personnel experiencing gastrointestinal issues related to stress or infections.
✕Less likely to help
Patients with gastrointestinal disorders unrelated to stress or military service may not benefit from this research.
What this research studies
This research investigates the role of the LPA1 receptor in the enteric nervous system and its impact on gastrointestinal health, particularly in military personnel. It focuses on understanding how stress and infections can lead to gastrointestinal disorders like irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). By studying the interactions between the enteric nervous system and the intestinal epithelial barrier, the research aims to uncover mechanisms that could improve gut health and motility. The approach includes using animal models to explore the effects of LPA1 signaling on gut function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for gastrointestinal disorders that affect military personnel and potentially others with similar conditions.
How similar studies have gone: Previous research has shown promising results in understanding the role of the enteric nervous system in gut health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Veterans Health Administration
Decatur, United States Active
Researchers
- Principal investigator: Yun, Changhyon Chris — Veterans Health Administration
- Study coordinator: Yun, Changhyon Chris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.