How a specific receptor affects chronic sinus issues caused by rhinovirus infections
Interactions between RV-C and its receptor CDHR3 in the development of chronic rhinosinusitis
This study is looking at how a specific gene related to a receptor in your body might affect the severity of chronic rhinosinusitis (CRS) when you catch a cold from a certain type of virus, with the goal of finding better treatments for people with CRS.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10671731 on NIH RePORTER |
What this research studies
This research investigates the role of the CDHR3 receptor in the development of chronic rhinosinusitis (CRS) exacerbated by rhinovirus infections, particularly focusing on the RV-C species. It aims to understand how a genetic variant (rs6967330) in the CDHR3 receptor influences the severity of symptoms in CRS patients. By studying tissue samples and conducting in vitro experiments, the research seeks to identify different molecular responses to RV-C infections compared to other rhinovirus types. This could lead to better-targeted treatments for individuals suffering from CRS.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with chronic rhinosinusitis, especially those who carry the rs6967330 genetic variant.
Not a fit: Patients without chronic rhinosinusitis or those who do not carry the rs6967330 allele may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with chronic rhinosinusitis, particularly those affected by rhinovirus infections.
How similar studies have performed: Previous research has shown that understanding genetic factors in viral infections can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Chang, Eugene H — University of Arizona
- Study coordinator: Chang, Eugene H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.