How a specific protein regulation affects heart muscle growth and function
Official title: Regulation of SGK1-mediated Pathological Cardiac Hypertrophy by Non-Canonical ERAD
Funded at University of Arizona · NIH-10995585 · Data updated 2026-11-12
This study is looking at how a protein called SGK1 affects the heart when it gets too big due to high blood pressure, and it aims to find new ways to keep hearts healthy and prevent heart failure, which could help patients with heart conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | December 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $40,591 |
| NIH project number | 1F31HL172675-01A1 |
| Project ID | NIH-10995585 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of hypertension or early signs of cardiac hypertrophy.
✕Less likely to help
Patients with non-cardiac related health issues or those without any signs of heart disease may not benefit from this research.
What this research studies
This research investigates the role of a protein called SGK1 in the development of pathological cardiac hypertrophy, which is an abnormal enlargement of the heart muscle often caused by high blood pressure. The study focuses on understanding how the body manages protein levels in heart cells, particularly how misfolded proteins are recognized and degraded. By exploring the mechanisms of protein degradation in heart cells, the research aims to uncover new insights into maintaining heart health and preventing heart failure. Patients may benefit from findings that could lead to new treatments for heart conditions related to abnormal heart muscle growth.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating heart failure caused by pathological cardiac hypertrophy.
How similar studies have gone: Previous research has shown promising results in understanding protein degradation mechanisms in heart diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Bagchi, Sukriti — University of Arizona
- Study coordinator: Bagchi, Sukriti
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.