How a specific protein regulation affects heart muscle growth and function
Regulation of SGK1-mediated Pathological Cardiac Hypertrophy by Non-Canonical ERAD
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF ARIZONA · NIH-10995585
This study is looking at how a protein called SGK1 affects the heart when it gets too big due to high blood pressure, and it aims to find new ways to keep hearts healthy and prevent heart failure, which could help patients with heart conditions.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-10995585 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called SGK1 in the development of pathological cardiac hypertrophy, which is an abnormal enlargement of the heart muscle often caused by high blood pressure. The study focuses on understanding how the body manages protein levels in heart cells, particularly how misfolded proteins are recognized and degraded. By exploring the mechanisms of protein degradation in heart cells, the research aims to uncover new insights into maintaining heart health and preventing heart failure. Patients may benefit from findings that could lead to new treatments for heart conditions related to abnormal heart muscle growth.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of hypertension or early signs of cardiac hypertrophy.
Not a fit: Patients with non-cardiac related health issues or those without any signs of heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating heart failure caused by pathological cardiac hypertrophy.
How similar studies have performed: Previous research has shown promising results in understanding protein degradation mechanisms in heart diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAGCHI, SUKRITI — UNIVERSITY OF ARIZONA
- Study coordinator: BAGCHI, SUKRITI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer cell